| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor Par1Orphan Nuclear Receptor PxrPregnane X ReceptorSteroid And Xenobiotic ReceptorSxr |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 O75469-1 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Nuclear Receptor Subfamily 1 Group I Member 2 proteinOrphan Nuclear Receptor Par1 proteinOrphan Nuclear Receptor Pxr proteinPregnane X Receptor proteinSteroid And Xenobiotic Receptor proteinSxr proteinNR1I2 proteinPXR protein |
Information sourced from Uniprot.org
