SDS-PAGE gel of recombinant human NMNAT-1 protein under reducing conditions stained with Coomassie blue

Human NMNAT-1 protein (Recombinant) (His-Tag) (STJP016783)

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STJP016783
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Short Description :Recombinant-Human NMNAT-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 0.1M NaCl, 1mM DTT, 1mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NMNAT1
Gene ID:64802
Uniprot ID:NMNA1_HUMAN
Accession Number:NP_073624
Immunogen:Human
Immunogen Region:1-279aa
Immunogen Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMENS EKTEVVLLAC GSFNPITNMH LRLFELAKDY MNGTGRYTVV KGIISPVGDA YKKKGLIPAY HRVIMAELAT KNSKWVEVDT WESLQKEWKE TLKVLRHHQE KLEASDCDHQ QNSPTLERPG RKRKWTETQD SSQKKSLEPK TKAVPKVKLL CGADLLESFA VPNLWKSEDI TQIVANYGLI CVTRAGND
Tissue Specificity Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain.
Function Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults. Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity.
Protein Name Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1
Nmn/Namn Adenylyltransferase 1
Nicotinamide-Nucleotide Adenylyltransferase 1
Nmn Adenylyltransferase 1
Nicotinate-Nucleotide Adenylyltransferase 1
Namn Adenylyltransferase 1
Database Links Reactome: R-HSA-196807
Cellular Localisation Nucleus
Alternative Protein Names Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1 protein
Nmn/Namn Adenylyltransferase 1 protein
Nicotinamide-Nucleotide Adenylyltransferase 1 protein
Nmn Adenylyltransferase 1 protein
Nicotinate-Nucleotide Adenylyltransferase 1 protein
Namn Adenylyltransferase 1 protein
NMNAT1 protein
NMNAT protein

Information sourced from Uniprot.org

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