Human NHP2 protein (Recombinant) (His-Tag) (STJP017003)

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STJP017003
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Short Description :Recombinant-Human NHP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NHP2
Gene ID:55651
Uniprot ID:NHP2_HUMAN
Accession Number:NP_060308
Immunogen:Human
Immunogen Region:1-153aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MTKIKADPDG PEAQAEACSG ERTYQELLVN QNPIAQPLAS RRLTRKLYKC IKKAVKQKQI RRGVKEVQKF VNKGEKGIMV LAGDTLPIEV YCHLPVMCED RNLPYVYIPS KTDLGAAAGS KRPTCVIMVK PHEEYQEAYD ECLEEVQSLP LPL
Tissue Specificity Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
Function Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Protein Name H/Aca Ribonucleoprotein Complex Subunit 2
Nucleolar Protein Family A Member 2
Snornp Protein Nhp2
Database Links Reactome: R-HSA-171319
Reactome: R-HSA-6790901
Cellular Localisation Nucleus
Nucleolus
Cajal Body
Also Localized To Cajal Bodies (Coiled Bodies)
Alternative Protein Names H/Aca Ribonucleoprotein Complex Subunit 2 protein
Nucleolar Protein Family A Member 2 protein
Snornp Protein Nhp2 protein
NHP2 protein
NOLA2 protein
HSPC286 protein

Information sourced from Uniprot.org

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