| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Nectin-3/PVRL3/CD113-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Nectin-1 at 3 Mu g/mL (100 Mu L/well) can bind Recombinant Human Nectin-3 with a linear range of 180-720 ng/mL. |
| Gene Symbol: |
NECTIN3 |
| Gene ID: |
25945 |
| Uniprot ID: |
NECT3_HUMAN |
| Immunogen: |
Recombinant Human Nectin-3/PVRL3/CD113 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gly 58-Asp 400 ) of human Nectin 3 (Accession #NP_056295) fused with an Fc, 6×His tag at the C-terminus. |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
| Function | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. |
| Protein Name | Nectin-3Cdw113Nectin Cell Adhesion Molecule 3Poliovirus Receptor-Related Protein 3Cd Antigen Cd113 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Protein Names | Nectin-3 proteinCdw113 proteinNectin Cell Adhesion Molecule 3 proteinPoliovirus Receptor-Related Protein 3 proteinCd Antigen Cd113 proteinNECTIN3 proteinPRR3 proteinPVRL3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
