• Human Nectin-3/PVRL3/CD113 protein (Recombinant) (C-hFc&His) (STJP001084)
  • Human Nectin-3/PVRL3/CD113 protein (Recombinant) (C-hFc&His) (STJP001084)
  • Human Nectin-3/PVRL3/CD113 protein (Recombinant) (C-hFc&His) (STJP001084)
  • Human Nectin-3/PVRL3/CD113 protein (Recombinant) (C-hFc&His) (STJP001084)

Human Nectin-3/PVRL3/CD113 protein (Recombinant) (C-hFc&His) (STJP001084)

SKU:
STJP001084

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Nectin-3/PVRL3/CD113-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Nectin-1 at 3 Mu g/mL (100 Mu L/well) can bind Recombinant Human Nectin-3 with a linear range of 180-720 ng/mL.
Gene Symbol: NECTIN3
Gene ID: 25945
Uniprot ID: NECT3_HUMAN
Immunogen: Recombinant Human Nectin-3/PVRL3/CD113 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gly 58-Asp 400 ) of human Nectin 3 (Accession #NP_056295) fused with an Fc, 6Ă—His tag at the C-terminus.
Tissue Specificity Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Protein Name Nectin-3
Cdw113
Nectin Cell Adhesion Molecule 3
Poliovirus Receptor-Related Protein 3
Cd Antigen Cd113
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Protein Names Nectin-3 protein
Cdw113 protein
Nectin Cell Adhesion Molecule 3 protein
Poliovirus Receptor-Related Protein 3 protein
Cd Antigen Cd113 protein
NECTIN3 protein
PRR3 protein
PVRL3 protein

Information sourced from Uniprot.org

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