• Biotinylated Human Nectin-3 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
  • The purity of Biotinylated Human Nectin-3 is greater than 95% as determined by SEC-HPLC.
  • Biotinylated Human Nectin-3, His Tag immobilized on CM5 Chip can bind Human Nectin-1, His Tag with an affinity constant of 0. 13 Mu M as determined in SPR assay (Biacore T200).

Human Nectin-3/CD113 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001594)

SKU:
STJP001594

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Nectin-3/CD113-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: NECTIN3
Gene ID: 25945
Uniprot ID: NECT3_HUMAN
Immunogen Region: Gly58-Asp400
Immunogen: DNA sequence encoding Human Nectin-3/CD113 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Protein Name Nectin-3
Cdw113
Nectin Cell Adhesion Molecule 3
Poliovirus Receptor-Related Protein 3
Cd Antigen Cd113
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Protein Names Nectin-3 protein
Cdw113 protein
Nectin Cell Adhesion Molecule 3 protein
Poliovirus Receptor-Related Protein 3 protein
Cd Antigen Cd113 protein
NECTIN3 protein
PRR3 protein
PVRL3 protein

Information sourced from Uniprot.org

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