| Post Translational Modifications | Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. Methylated by CARM1. Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Protein Name | Nuclear Receptor Coactivator 3Ncoa-3ActrAmplified In Breast Cancer 1 ProteinAib-1Cbp-Interacting ProteinPcipClass E Basic Helix-Loop-Helix Protein 42Bhlhe42Receptor-Associated Coactivator 3Rac-3Steroid Receptor Coactivator Protein 3Src-3Thyroid Hormone Receptor Activator Molecule 1Tram-1 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381340Reactome: R-HSA-5617472Reactome: R-HSA-5687128Reactome: R-HSA-9018519 |
| Cellular Localisation | CytoplasmNucleusMainly Cytoplasmic And Weakly NuclearUpon Tnf Activation And Subsequent PhosphorylationIt Translocates From The Cytoplasm To The Nucleus |
| Alternative Protein Names | Nuclear Receptor Coactivator 3 proteinNcoa-3 proteinActr proteinAmplified In Breast Cancer 1 Protein proteinAib-1 proteinCbp-Interacting Protein proteinPcip proteinClass E Basic Helix-Loop-Helix Protein 42 proteinBhlhe42 proteinReceptor-Associated Coactivator 3 proteinRac-3 proteinSteroid Receptor Coactivator Protein 3 proteinSrc-3 proteinThyroid Hormone Receptor Activator Molecule 1 proteinTram-1 proteinNCOA3 proteinAIB1 proteinBHLHE42 proteinRAC3 proteinTRAM1 protein |
Information sourced from Uniprot.org
