Human NCOA1 protein (Recombinant) (N-His) (STJP015944)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NCOA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | NCOA1 |
| Gene ID | 8648 |
| Uniprot ID | NCOA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val106-Gly370 |
Additional Info
| Post Translational Modifications | Sumoylated.sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein. Ubiquitinated.leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4.the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. |
| Protein Name | Nuclear Receptor Coactivator 1Ncoa-1Class E Basic Helix-Loop-Helix Protein 74Bhlhe74Protein Hin-2Rip160Renal Carcinoma Antigen Ny-Ren-52Steroid Receptor Coactivator 1Src-1 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-159418Reactome: R-HSA-192105Reactome: R-HSA-193368Reactome: R-HSA-193807Reactome: R-HSA-1989781Reactome: R-HSA-211976Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-3214847Reactome: R-HSA-381340Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9029569Reactome: R-HSA-9623433Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9841922Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Nuclear Receptor Coactivator 1 proteinNcoa-1 proteinClass E Basic Helix-Loop-Helix Protein 74 proteinBhlhe74 proteinProtein Hin-2 proteinRip160 proteinRenal Carcinoma Antigen Ny-Ren-52 proteinSteroid Receptor Coactivator 1 proteinSrc-1 proteinNCOA1 proteinBHLHE74 proteinSRC1 protein |
Information sourced from Uniprot.org