Human MYO1G protein (Recombinant) (N-His) (STJP003121)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MYO1G-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MYO1G |
| Gene ID | 64005 |
| Uniprot ID | MYO1G_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly769-Pro1016 |
Additional Info
| Function | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. |
| Protein Name | Unconventional Myosin-Ig Cleaved Into - Minor Histocompatibility Antigen Ha-2Mhag Ha-2 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell ProjectionPhagocytic CupRecruited To Fc-Gamma Receptor (Fc-Gamma-R) Phagocytic CupIn T-CellsTransiently Accumulates In Discrete Areas At The Plasma Membrane Of Migrating Cells Or When Membranes Are DeformedLocalization At The Membrane Is Not Highly Dependent On Phosphatidylinositol 45-Bisphosphate LevelsReleased From The Membrane In The Presence Of AtpMay Be Enriched In Peripheral ProcessesSuch As Microvilli Or Ruffles |
| Alternative Protein Names | Unconventional Myosin-Ig Cleaved Into - Minor Histocompatibility Antigen Ha-2 proteinMhag Ha-2 proteinMYO1G proteinHA2 protein |
Information sourced from Uniprot.org