Human MYO1C protein (Recombinant) (N-GST) (STJP003125)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MYO1C-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MYO1C |
| Gene ID | 4641 |
| Uniprot ID | MYO1C_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln765-Asn1011 |
Additional Info
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Isoform 3: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. |
| Protein Name | Unconventional Myosin-IcMyosin I BetaMmi-BetaMmib |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-2029482Reactome: R-HSA-5250924 O00159-3Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmNucleusCell CortexCell ProjectionStereocilium MembraneCytoplasmic VesicleRuffle MembraneColocalizes With Cabp1 And Cib1 At Cell MarginMembrane Ruffles And Punctate Regions On The Cell MembraneColocalizes In Adipocytes With Glut4 At Actin-Based MembranesColocalizes With Glut4 At Insulin-Induced Ruffles At The Cell MembraneLocalizes Transiently At Cell Membrane To Region Known To Be Enriched In Pip2Activation Of Phospholipase C Results In Its Redistribution To The CytoplasmColocalizes With Rna Polymerase IiTranslocates To Nuclear Speckles Upon Exposure To Inhibitors Of Rna Polymerase Ii TranscriptionIsoform 3: NucleusNucleoplasmNucleolusColocalizes With Rna Polymerase Ii In The NucleusColocalizes With Rna Polymerase I In NucleoliIn The NucleolusIs Localized Predominantly In Dense Fibrillar Component (Dfc) And In Granular Component (Gc)Accumulates Strongly In Dfc And Gc During Activation Of TranscriptionColocalizes With Transcription SitesColocalizes In The Granular Cortex At The Periphery Of The Nucleolus With Rps6Colocalizes In Nucleoplasm With Rps6 And Actin That Are In Contact With Rnp ParticlesColocalizes With Rps6 At The Nuclear Pore Level |
| Alternative Protein Names | Unconventional Myosin-Ic proteinMyosin I Beta proteinMmi-Beta proteinMmib proteinMYO1C protein |
Information sourced from Uniprot.org