| Short Description : | Recombinant-Human MS4A1/CD20-C-His&Avi protein was developed in e.coli using the region Ile141-Ser188. For use in research applications. |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as 0.22 Mu m filtered solution in 20 mM PB, 10% Glycerol, 0.4 M Urea, 1 mM GSH, 0.1 mM GSSG (pH 7.0). |
| Storage Instruction: | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | MS4A1 |
| Gene ID: | 931 |
| Uniprot ID: | CD20_HUMAN |
| Immunogen: | Recombinant Human MS4A1/CD20 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ile141-Ser188) of Human MS4A1/CD20 (Accession #P11836-1) fused with a C-His&Avi tag at the C-terminus. |
| Immunogen Region: | Ile141-Ser188 |
| Immunogen Sequence: | IKISHFLKMESLNFIRAHTP YINIYNCEPANPSEKNSPST QYCYSIQS |
| Tissue Specificity | Expressed on B-cells. |
| Post Translational Modifications | Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate. |
| Function | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. |
| Protein Name | B-Lymphocyte Antigen Cd20B-Lymphocyte Surface Antigen B1Bp35Leukocyte Surface Antigen Leu-16Membrane-Spanning 4-Domains Subfamily A Member 1Cd Antigen Cd20 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLipid-AnchorConstitutively Associated With Membrane Rafts |
| Alternative Protein Names | B-Lymphocyte Antigen Cd20 proteinB-Lymphocyte Surface Antigen B1 proteinBp35 proteinLeukocyte Surface Antigen Leu-16 proteinMembrane-Spanning 4-Domains Subfamily A Member 1 proteinCd Antigen Cd20 proteinMS4A1 proteinCD20 protein |
Information sourced from Uniprot.org