| Post Translational Modifications | Phosphorylated by PINK1. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion.deubiquitination by USP30 inhibits mitochondrial fusion. Ubiquitinated by HUWE1 when dietary stearate (C18:0) levels are low.ubiquitination inhibits mitochondrial fusion. |
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. |
| Protein Name | Mitofusin-2Transmembrane Gtpase Mfn2 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-9013419Reactome: R-HSA-983231 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinColocalizes With Bax During Apoptosis |
| Alternative Protein Names | Mitofusin-2 proteinTransmembrane Gtpase Mfn2 proteinMFN2 proteinCPRP1 proteinKIAA0214 protein |
Information sourced from Uniprot.org
