Human H6PD protein (Recombinant) (N-His) (STJP003434)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human H6PD-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | H6PD |
| Gene ID | 9563 |
| Uniprot ID | G6PE_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln20-Gln526 |
Additional Info
| Function | Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity. |
| Protein Name | Gdh/6pgl Endoplasmic Bifunctional Protein Includes - Hexose-6-Phosphate DehydrogenaseGlucose 1-DehydrogenaseGdhGlucose-6-Phosphate Dehydrogenase - 6-Phosphogluconolactonase6pgl |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Protein Names | Gdh/6pgl Endoplasmic Bifunctional Protein Includes - Hexose-6-Phosphate Dehydrogenase proteinGlucose 1-Dehydrogenase proteinGdh proteinGlucose-6-Phosphate Dehydrogenase - 6-Phosphogluconolactonase protein6pgl proteinH6PD proteinGDH protein |
Information sourced from Uniprot.org