| Function | Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif Ala/Gly/Pro/Ser-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the Ala/Gly/Ser-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. |
| Protein Name | N-Terminal Xaa-Pro-Lys N-Methyltransferase 1Alpha N-Terminal Protein Methyltransferase 1aMethyltransferase-Like Protein 11aN-Terminal Rcc1 MethyltransferaseX-Pro-Lys N-Terminal Protein Methyltransferase 1aNtm1a Cleaved Into - N-Terminal Xaa-Pro-Lys N-Methyltransferase 1 - N-Terminally Processed |
| Database Links | |
| Cellular Localisation | NucleusPredominantly Nuclear |
| Alternative Protein Names | N-Terminal Xaa-Pro-Lys N-Methyltransferase 1 proteinAlpha N-Terminal Protein Methyltransferase 1a proteinMethyltransferase-Like Protein 11a proteinN-Terminal Rcc1 Methyltransferase proteinX-Pro-Lys N-Terminal Protein Methyltransferase 1a proteinNtm1a Cleaved Into - N-Terminal Xaa-Pro-Lys N-Methyltransferase 1 - N-Terminally Processed proteinNTMT1 proteinC9orf32 proteinMETTL11A proteinNRMT proteinNRMT1 proteinAD-003 protein |
Information sourced from Uniprot.org
