| Post Translational Modifications | Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus. Phosphorylation increases its interaction with PSIP1. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 1Activator-Recruited Cofactor 205 Kda ComponentArc205Mediator Complex Subunit 1Peroxisome Proliferator-Activated Receptor-Binding ProteinPbpPpar-Binding ProteinThyroid Hormone Receptor-Associated Protein Complex 220 Kda ComponentTrap220Thyroid Receptor-Interacting Protein 2Tr-Interacting Protein 2Trip-2Vitamin D Receptor-Interacting Protein Complex Component Drip205P53 Regulatory Protein Rb18a |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9833110 |
| Cellular Localisation | NucleusA Subset Of The Protein May Enter The Nucleolus Subsequent To Phosphorylation By Mapk1 Or Mapk3 |
| Alternative Protein Names | Mediator Of Rna Polymerase Ii Transcription Subunit 1 proteinActivator-Recruited Cofactor 205 Kda Component proteinArc205 proteinMediator Complex Subunit 1 proteinPeroxisome Proliferator-Activated Receptor-Binding Protein proteinPbp proteinPpar-Binding Protein proteinThyroid Hormone Receptor-Associated Protein Complex 220 Kda Component proteinTrap220 proteinThyroid Receptor-Interacting Protein 2 proteinTr-Interacting Protein 2 proteinTrip-2 proteinVitamin D Receptor-Interacting Protein Complex Component Drip205 proteinP53 Regulatory Protein Rb18a proteinMED1 proteinARC205 proteinCRSP1 proteinCRSP200 proteinDRIP205 proteinDRIP230 proteinPBP proteinPPARBP proteinPPARGBP proteinRB18A proteinTRAP220 proteinTRIP2 protein |
Information sourced from Uniprot.org
