Human MCTS1 protein (Recombinant) (N-His) (STJP006193)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MCTS1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MCTS1 |
| Gene ID | 28985 |
| Uniprot ID | MCTS1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys181 |
Additional Info
| Post Translational Modifications | Phosphorylation is critical for stabilization and promotion of cell proliferation. |
| Function | Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2. |
| Protein Name | Malignant T-Cell-Amplified Sequence 1Mct-1Multiple Copies T-Cell Malignancies |
| Database Links | |
| Cellular Localisation | CytoplasmNuclear Relocalization After Dna Damage |
| Alternative Protein Names | Malignant T-Cell-Amplified Sequence 1 proteinMct-1 proteinMultiple Copies T-Cell Malignancies proteinMCTS1 proteinMCT1 protein |
Information sourced from Uniprot.org