| Post Translational Modifications | Sumoylated, sumoylation may increase interaction with ATF7IP. |
| Function | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 1Cxxc-Type Zinc Finger Protein 3Methyl-Cpg-Binding Protein Mbd1Protein Containing Methyl-Cpg-Binding Domain 1 |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | NucleusNucleus MatrixNucleus SpeckleChromosomeNuclearIn A Punctate PatternAssociated With Euchromatic Regions Of The ChromosomesWith Pericentromeric Regions On Chromosome 1 And With Telomeric Regions From Several Chromosomes |
| Alternative Protein Names | Methyl-Cpg-Binding Domain Protein 1 proteinCxxc-Type Zinc Finger Protein 3 proteinMethyl-Cpg-Binding Protein Mbd1 proteinProtein Containing Methyl-Cpg-Binding Domain 1 proteinMBD1 proteinCXXC3 proteinPCM1 protein |
Information sourced from Uniprot.org
