| Host: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
GDNF |
| Gene ID: |
2668 |
| Uniprot ID: |
GDNF_HUMAN |
| Immunogen Region: |
Arg109-Ile211 |
| Immunogen: |
Recombinant Human Mature GDNF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg109-Ile211) of Human Mature GDNF (Accession #NP_000505.1) fused with a His tag at the N-terminus. |
| Immunogen Sequence: |
RGQRGKNRGCVLTAIHLNVT DLGLGYETKEELIFRYCSGS CDAAETTYDKILKNLSRNRR LVSDKVGQACCRPIAFDDDL SFLDDNLVYHILRKHSAKRC GCI |
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest. |
| Protein Name | Glial Cell Line-Derived Neurotrophic FactorHgdnfAstrocyte-Derived Trophic FactorAtf |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Glial Cell Line-Derived Neurotrophic Factor proteinHgdnf proteinAstrocyte-Derived Trophic Factor proteinAtf proteinGDNF protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
