| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human GDNF-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human GDNF at 1 Mu g/mL (100 Mu L/well) can bind Human GFRA1 with a linear range of 2-332 ng/mL. |
| Gene Symbol: |
GDNF |
| Gene ID: |
2668 |
| Uniprot ID: |
GDNF_HUMAN |
| Immunogen Region: |
Arg109-Ile211 |
| Immunogen: |
Recombinant Human GDNF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg109-Ile211) of human GDNF (Accession #NP_000505.1) fused with an 6×His tag at the C-terminus. |
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. |
| Protein Name | Glial Cell Line-Derived Neurotrophic FactorHgdnfAstrocyte-Derived Trophic FactorAtf |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Glial Cell Line-Derived Neurotrophic Factor proteinHgdnf proteinAstrocyte-Derived Trophic Factor proteinAtf proteinGDNF protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
