Human MARK1 protein (Recombinant) (N-His) (STJP016370)

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STJP016370
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Short Description :Recombinant-Human MARK1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:MARK1
Gene ID:4139
Uniprot ID:MARK1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gly58-Lys371
Post Translational Modifications Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity. Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity.
Function Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Protein Name Serine/Threonine-Protein Kinase Mark1
Map/Microtubule Affinity-Regulating Kinase 1
Par1 Homolog C
Par-1c
Par1c
Database Links
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasm
Cytoskeleton
Cell Projection
Dendrite
Appears To Localize To An Intracellular Network
Alternative Protein Names Serine/Threonine-Protein Kinase Mark1 protein
Map/Microtubule Affinity-Regulating Kinase 1 protein
Par1 Homolog C protein
Par-1c protein
Par1c protein
MARK1 protein
KIAA1477 protein
MARK protein

Information sourced from Uniprot.org

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