Human MAPRE2 protein (Recombinant) (N-His) (STJP016253)

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STJP016253
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MAPRE2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: MAPRE2
Gene ID: 10982
Uniprot ID: MARE2_HUMAN
Immunogen Region: Ser59-Pro182
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated at Ser-236 by CK2 leading to enhanced cell adhesion. Phosphorylated by CDK1 and AURKB during mitosis reduces the binding affinity of MAPRE2 for microtubules. Ubiquitinated in an ASB14-dependent manner.leading to proteasomal degradation.
Function Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability. Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation. Plays a role during oocyte meiosis by regulating microtubule dynamics. Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics.
Protein Name Microtubule-Associated Protein Rp/Eb Family Member 2
Apc-Binding Protein Eb2
End-Binding Protein 2
Eb2
Database Links
Cellular Localisation Cytoplasm
Cytoskeleton
Associated With The Microtubule Network
Accumulates At The Plus End Of Microtubules
Alternative Protein Names Microtubule-Associated Protein Rp/Eb Family Member 2 protein
Apc-Binding Protein Eb2 protein
End-Binding Protein 2 protein
Eb2 protein
MAPRE2 protein
RP1 protein

Information sourced from Uniprot.org

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