Human MAPRE2 protein (Recombinant) (N-His) (STJP016253)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAPRE2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | MAPRE2 |
| Gene ID | 10982 |
| Uniprot ID | MARE2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser59-Pro182 |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-236 by CK2 leading to enhanced cell adhesion. Phosphorylated by CDK1 and AURKB during mitosis reduces the binding affinity of MAPRE2 for microtubules. Ubiquitinated in an ASB14-dependent manner.leading to proteasomal degradation. |
| Function | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability. Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation. Plays a role during oocyte meiosis by regulating microtubule dynamics. Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics. |
| Protein Name | Microtubule-Associated Protein Rp/Eb Family Member 2Apc-Binding Protein Eb2End-Binding Protein 2Eb2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonAssociated With The Microtubule NetworkAccumulates At The Plus End Of Microtubules |
| Alternative Protein Names | Microtubule-Associated Protein Rp/Eb Family Member 2 proteinApc-Binding Protein Eb2 proteinEnd-Binding Protein 2 proteinEb2 proteinMAPRE2 proteinRP1 protein |
Information sourced from Uniprot.org