Human LRP4 protein (Recombinant) (C-His) (STJP012363)
SPECIFICATIONS
HostMammalian cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LRP4-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 2% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
Target Information
| Gene Symbol | LRP4 |
| Gene ID | 4038 |
| Uniprot ID | LRP4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser21-Ser1725 |
Additional Info
| Function | Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation. |
| Protein Name | Low-Density Lipoprotein Receptor-Related Protein 4Lrp-4Multiple Epidermal Growth Factor-Like Domains 7 |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Low-Density Lipoprotein Receptor-Related Protein 4 proteinLrp-4 proteinMultiple Epidermal Growth Factor-Like Domains 7 proteinLRP4 proteinKIAA0816 proteinLRP10 proteinMEGF7 protein |
Information sourced from Uniprot.org