Human LILRB2/ILT-4/CD85d protein (Recombinant) (C-His) (STJP001032)

Human LILRB2/ILT-4/CD85d protein (Recombinant) (C-His) (STJP001032)

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STJP001032
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human LILRB2 at 4 Mu g/mL (100 Mu L/well) can bind Recombinant Human ANGPTL7 with a linear range of 0.18-0.72 Mu g/mL.
Gene Symbol: LILRB2
Gene ID: 10288
Uniprot ID: LIRB2_HUMAN
Immunogen: Recombinant Human LILRB2/ILT-4/CD85d Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 22-Val 461 ) of human LILRB2/CD85d/ILT4 (Accession #AAB87662) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: QTGTIPKPTLWAEPDSVITQ GSPVTLSCQGSLEAQEYRLY REKKSASWITRIRPELVKNG QFHIPSITWEHTGRYGCQYY SRARWSELSDPLVLVMTGAY PKPTLSAQPSPVVTSGGRVT LQCESQVAFGGFILCKEGED EHPQCLNSQPHARGSSRAIF SVGPVSPNRRWSHRCYGYDL NSPYVWSSPSDLLELLVPGV SKKPSLSVQPGPVVAPGESL TLQCVSDVGYDRFVLYKEG
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2
Lir-2
Leukocyte Immunoglobulin-Like Receptor 2
Cd85 Antigen-Like Family Member D
Immunoglobulin-Like Transcript 4
Ilt-4
Monocyte/Macrophage Immunoglobulin-Like Receptor 10
Mir-10
Cd Antigen Cd85d
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 protein
Lir-2 protein
Leukocyte Immunoglobulin-Like Receptor 2 protein
Cd85 Antigen-Like Family Member D protein
Immunoglobulin-Like Transcript 4 protein
Ilt-4 protein
Monocyte/Macrophage Immunoglobulin-Like Receptor 10 protein
Mir-10 protein
Cd Antigen Cd85d protein
LILRB2 protein
ILT4 protein
LIR2 protein
MIR10 protein

Information sourced from Uniprot.org

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