| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human LILRB2 at 4 Mu g/mL (100 Mu L/well) can bind Recombinant Human ANGPTL7 with a linear range of 0.18-0.72 Mu g/mL. |
| Gene Symbol: | LILRB2 |
| Gene ID: | 10288 |
| Uniprot ID: | LIRB2_HUMAN |
| Immunogen: | Recombinant Human LILRB2/ILT-4/CD85d Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 22-Val 461 ) of human LILRB2/CD85d/ILT4 (Accession #AAB87662) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | QTGTIPKPTLWAEPDSVITQ GSPVTLSCQGSLEAQEYRLY REKKSASWITRIRPELVKNG QFHIPSITWEHTGRYGCQYY SRARWSELSDPLVLVMTGAY PKPTLSAQPSPVVTSGGRVT LQCESQVAFGGFILCKEGED EHPQCLNSQPHARGSSRAIF SVGPVSPNRRWSHRCYGYDL NSPYVWSSPSDLLELLVPGV SKKPSLSVQPGPVVAPGESL TLQCVSDVGYDRFVLYKEG |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 Lir-2 Leukocyte Immunoglobulin-Like Receptor 2 Cd85 Antigen-Like Family Member D Immunoglobulin-Like Transcript 4 Ilt-4 Monocyte/Macrophage Immunoglobulin-Like Receptor 10 Mir-10 Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 protein Lir-2 protein Leukocyte Immunoglobulin-Like Receptor 2 protein Cd85 Antigen-Like Family Member D protein Immunoglobulin-Like Transcript 4 protein Ilt-4 protein Monocyte/Macrophage Immunoglobulin-Like Receptor 10 protein Mir-10 protein Cd Antigen Cd85d protein LILRB2 protein ILT4 protein LIR2 protein MIR10 protein |
Information sourced from Uniprot.org