| Post Translational Modifications | Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. |
| Function | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. |
| Protein Name | Lim Domain-Binding Protein 1Ldb-1Carboxyl-Terminal Lim Domain-Binding Protein 2Clim-2Lim Domain-Binding Factor Clim2Hldb1Nuclear Lim Interactor |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9010553Reactome: R-HSA-9733709Reactome: R-HSA-9752946 |
| Cellular Localisation | NucleusColocalizes With Slk At Leading Edges |
| Alternative Protein Names | Lim Domain-Binding Protein 1 proteinLdb-1 proteinCarboxyl-Terminal Lim Domain-Binding Protein 2 proteinClim-2 proteinLim Domain-Binding Factor Clim2 proteinHldb1 proteinNuclear Lim Interactor proteinLDB1 proteinCLIM2 protein |
Information sourced from Uniprot.org
