Human KLRB1/CD161 protein (Recombinant) (C-His) (STJP019895)

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STJP019895-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: KLRB1
Gene ID: 3820
Uniprot ID: KLRB1_HUMAN
Immunogen Region: Gln67-Ser225
Immunogen: Recombinant Human KLRB1/CD161 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln67-Ser225) of Human KLRB1/CD161 (Accession #Q12918-1) fused with a C-His tag at the C-terminus.
Immunogen Sequence: QKSSIEKCSVDIQQSRNKTT ERPGLLNCPIYWQQLREKCL LFSHTVNPWNNSLADCSTKE SSLLLIRDKDELIHTQNLIR DKAILFWIGLNFSLSEKNWK WINGSFLNSNDLEIRGDAKE NSCISISQTSVYSEYCSTEI RWICQKELTPVRNKVYPDS
Tissue Specificity Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Name Killer Cell Lectin-Like Receptor Subfamily B Member 1
C-Type Lectin Domain Family 5 Member B
Hnkr-P1a
Nkr-P1a
Natural Killer Cell Surface Protein P1a
Cd Antigen Cd161
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Killer Cell Lectin-Like Receptor Subfamily B Member 1 protein
C-Type Lectin Domain Family 5 Member B protein
Hnkr-P1a protein
Nkr-P1a protein
Natural Killer Cell Surface Protein P1a protein
Cd Antigen Cd161 protein
KLRB1 protein
CLEC5B protein
NKRP1A protein

Information sourced from Uniprot.org

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