Human KDM5C protein (Recombinant) (N-His) (STJP007848)

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STJP007848
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KDM5C-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KDM5C
Gene ID: 8242
Uniprot ID: KDM5C_HUMAN
Immunogen Region: Leu394-Asp621
Immunogen: Homo sapiens (Human)
Function Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Protein Name Lysine-Specific Demethylase 5c
Histone Demethylase Jarid1c
Jumonji/Arid Domain-Containing Protein 1c
Protein Smcx
Protein Xe169
Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c
Database Links Reactome: R-HSA-3214842
Cellular Localisation Nucleus
Alternative Protein Names Lysine-Specific Demethylase 5c protein
Histone Demethylase Jarid1c protein
Jumonji/Arid Domain-Containing Protein 1c protein
Protein Smcx protein
Protein Xe169 protein
Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c protein
KDM5C protein
DXS1272E protein
JARID1C protein
SMCX protein
XE169 protein

Information sourced from Uniprot.org

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