Human KCNMB3 protein (Recombinant) (His-Tag) (STJP018897)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human KCNMB3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNMB3 |
| Gene ID | 27094 |
| Uniprot ID | KCMB3_HUMAN |
| Accession Number | NP_055222 |
| Immunogen | Human |
| Immunogen Region | 82-207aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSKPFMLSI QREESTCTAI HTDIMDDWLD CAFTCGVHCH GQGKYPCLQV FVNLSHPGQK ALLHYNEEAV QINPKCFYTP KCHQDRNDLL NSALDIKEFF DHKNGTPFSC FYSPASQSED VILIKKYDQ |
Additional Info
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. |
| Post Translational Modifications | N-glycosylated. The extracellular domain contains disulfide bond essential for the gating mechanism. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-3Bk Channel Subunit Beta-3Bkbeta3Hbeta3Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3Charybdotoxin Receptor Subunit Beta-3K(Vcabeta-3Maxi K Channel Subunit Beta-3Slo-Beta-3 |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Calcium-Activated Potassium Channel Subunit Beta-3 proteinBk Channel Subunit Beta-3 proteinBkbeta3 proteinHbeta3 proteinCalcium-Activated Potassium Channel - Subfamily M Subunit Beta-3 proteinCharybdotoxin Receptor Subunit Beta-3 proteinK(Vcabeta-3 proteinMaxi K Channel Subunit Beta-3 proteinSlo-Beta-3 proteinKCNMB3 proteinKCNMB2 proteinKCNMBL protein |
Information sourced from Uniprot.org