Human KCNJ10 protein (Recombinant) (N-His) (STJP005076)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KCNJ10-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KCNJ10 |
| Gene ID | 3766 |
| Uniprot ID | KCJ10_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe165-Val379 |
Additional Info
| Function | May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules.this process is critical for Na(+) reabsorption at the tubules. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 10Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1Inward Rectifier K(+ Channel Kir1.2Potassium Channel - Inwardly Rectifying Subfamily J Member 10 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296067Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIn Kidney Distal Convoluted TubulesLocated In The Basolateral Membrane Where It Colocalizes With Kcnj16 |
| Alternative Protein Names | Atp-Sensitive Inward Rectifier Potassium Channel 10 proteinAtp-Dependent Inwardly Rectifying Potassium Channel Kir4.1 proteinInward Rectifier K(+ Channel Kir1.2 proteinPotassium Channel - Inwardly Rectifying Subfamily J Member 10 proteinKCNJ10 protein |
Information sourced from Uniprot.org