Human KCNH2/ERG1 protein (Recombinant) (N-His-SUMO) (STJP008881)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KCNH2/ERG1-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KCNH2 |
| Gene ID | 3757 |
| Uniprot ID | KCNH2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro10-Lys135 |
Additional Info
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. |
| Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. Isoform A-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2Eag HomologEther-A-Go-Go-Related Gene Potassium Channel 1Erg-1Eag-Related Protein 1Ether-A-Go-Go-Related Protein 1H-ErgHerg-1Herg1Potassium Voltage-Gated Channel Subfamily H Member 2Voltage-Gated Potassium Channel Subunit Kv11.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2 proteinEag Homolog proteinEther-A-Go-Go-Related Gene Potassium Channel 1 proteinErg-1 proteinEag-Related Protein 1 proteinEther-A-Go-Go-Related Protein 1 proteinH-Erg proteinHerg-1 proteinHerg1 proteinPotassium Voltage-Gated Channel Subfamily H Member 2 proteinVoltage-Gated Potassium Channel Subunit Kv11.1 proteinKCNH2 proteinERG proteinERG1 proteinHERG protein |
Information sourced from Uniprot.org