| Function | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis. Also acetylates spermidine. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. |
| Protein Name | Histone Acetyltransferase Kat2bHistone Acetyltransferase PcafHistone Acetylase PcafLysine Acetyltransferase 2bP300/Cbp-Associated FactorP/CafSpermidine Acetyltransferase Kat2b |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-2032785Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214847Reactome: R-HSA-350054Reactome: R-HSA-5250924Reactome: R-HSA-5578768Reactome: R-HSA-5689901Reactome: R-HSA-73762Reactome: R-HSA-8936459Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9018519Reactome: R-HSA-9617629Reactome: R-HSA-9772755Reactome: R-HSA-9793380 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMainly Localizes To The NucleusAlso Localizes To Centrosomes In Late G1 And Around The G1/S TransitionCoinciding With The Onset Of Centriole FormationSubcellular Location May Vary Depending Upon Cell Differentiation StateCytoplasmic At The Very Stages Of Keratinocyte DifferentiationBecomes Nuclear At Later Differentiation StagesCytoplasmic In Basal Epithelial Cells (Undifferentiated Cells) And Nuclear In Parabasal Cells (Differentiated Cells)Localizes To Sites Of Dna Damage |
| Alternative Protein Names | Histone Acetyltransferase Kat2b proteinHistone Acetyltransferase Pcaf proteinHistone Acetylase Pcaf proteinLysine Acetyltransferase 2b proteinP300/Cbp-Associated Factor proteinP/Caf proteinSpermidine Acetyltransferase Kat2b proteinKAT2B proteinPCAF protein |
Information sourced from Uniprot.org
