| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Kallikrein-11/KLK11-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, pH 8.0. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Lys-ThioBenzyl ester (Z-Lys-SBzl) , in the presence of 5, 5 NA Dithio-bis (2-nitrobenzoic acid) (DTNB). The specific activity is >141.40 pmol/min/Mu g. |
| Gene Symbol: |
KLK11 |
| Gene ID: |
11012 |
| Uniprot ID: |
KLK11_HUMAN |
| Immunogen Region: |
Met1-Asn250 |
| Immunogen: |
Recombinant Human Kallikrein-11/KLK11 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Asn250) of human KLK11/Kallikrein-11 (Accession #NP_006844.1) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen. |
| Function | Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. |
| Protein Name | Kallikrein-11Hk11HippostasinSerine Protease 20Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Golgi Apparatus |
| Alternative Protein Names | Kallikrein-11 proteinHk11 proteinHippostasin proteinSerine Protease 20 proteinTrypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 proteinKLK11 proteinPRSS20 proteinTLSP proteinUNQ649 proteinPRO1279 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
