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Human IL-5 protein (Recombinant) (C-His) (STJP001312)

Human IL-5 protein (Recombinant) (C-His) (STJP001312)
Human IL-5 protein (Recombinant) (C-His) (STJP001312)
Human IL-5 protein (Recombinant) (C-His) (STJP001312)
Human IL-5 protein (Recombinant) (C-His) (STJP001312)

Human IL-5 protein (Recombinant) (C-His) (STJP001312)

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STJP001312

$137.03 - $482.63

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human IL-5-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity:	Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.5-2ng/mL.

Gene Symbol:	IL5
Gene ID:	3567
Uniprot ID:	IL5_HUMAN
Immunogen Region:	Ile20-Ser134
Immunogen:	Recombinant Human IL-5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile20-Ser134) of human IL-5 (Accession #NP_000870.1) fused with an 6×His tag at the C-terminus.

Function	Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
Protein Name	Interleukin-5 Il-5 B-Cell Differentiation Factor I Eosinophil Differentiation Factor T-Cell Replacing Factor Trf
Database Links	Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526
Cellular Localisation	Secreted
Alternative Protein Names	Interleukin-5 protein Il-5 protein B-Cell Differentiation Factor I protein Eosinophil Differentiation Factor protein T-Cell Replacing Factor protein Trf protein IL5 protein

Information sourced from Uniprot.org

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