• Human IL-5 protein (Recombinant) (C-His) (STJP001312)
  • Human IL-5 protein (Recombinant) (C-His) (STJP001312)
  • Human IL-5 protein (Recombinant) (C-His) (STJP001312)
  • Human IL-5 protein (Recombinant) (C-His) (STJP001312)

Human IL-5 protein (Recombinant) (C-His) (STJP001312)

SKU:
STJP001312

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-5-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.5-2ng/mL.
Gene Symbol: IL5
Gene ID: 3567
Uniprot ID: IL5_HUMAN
Immunogen Region: Ile20-Ser134
Immunogen: Recombinant Human IL-5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile20-Ser134) of human IL-5 (Accession #NP_000870.1) fused with an 6×His tag at the C-terminus.
Function Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
Protein Name Interleukin-5
Il-5
B-Cell Differentiation Factor I
Eosinophil Differentiation Factor
T-Cell Replacing Factor
Trf
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Secreted
Alternative Protein Names Interleukin-5 protein
Il-5 protein
B-Cell Differentiation Factor I protein
Eosinophil Differentiation Factor protein
T-Cell Replacing Factor protein
Trf protein
IL5 protein

Information sourced from Uniprot.org

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