Human IL-22RA2/IL22BP protein (Recombinant) (C-His) (STJP000965)

Human IL-22RA2/IL22BP protein (Recombinant) (C-His) (STJP000965)

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STJP000965
£106.50 - £359.50
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL22 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human IL22BP, the EC50 of Human IL22BP is 10.78 ng/mL.
Gene Symbol: IL22RA2
Gene ID: 116379
Uniprot ID: I22R2_HUMAN
Immunogen: Recombinant Human IL-22RA2/IL22BP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr22-Pro231) of human IL-22BP/IL-22RA2 (Accession #NP_851826.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: TQSTHESLKPQRVQFQSRNF HNILQWQPGRALTGNSSVYF VQYKIYGQRQWKNKEDCWGT QELSCDLTSETSDIQEPYYG RVRAASAGSYSEWSMTPRFT PWWETKIDPPVMNITQVNGS LLVILHAPNLPYRYQKEKNV SIEDYYELLYRVFIINNSLE KEQKVYEGAHRAVEIEALTP HSSYCVVAEIYQPMLDRRSQ RSEERCVEIP
Tissue Specificity Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
Function Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Protein Name Interleukin-22 Receptor Subunit Alpha-2
Il-22 Receptor Subunit Alpha-2
Il-22r-Alpha-2
Il-22ra2
Cytokine Receptor Class-Ii Member 10
Cytokine Receptor Family 2 Member 10
Crf2-10
Cytokine Receptor Family Type 2 - Soluble 1
Crf2-S1
Interleukin-22-Binding Protein
Il-22bp
Il22bp
Zcytor16
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Protein Names Interleukin-22 Receptor Subunit Alpha-2 protein
Il-22 Receptor Subunit Alpha-2 protein
Il-22r-Alpha-2 protein
Il-22ra2 protein
Cytokine Receptor Class-Ii Member 10 protein
Cytokine Receptor Family 2 Member 10 protein
Crf2-10 protein
Cytokine Receptor Family Type 2 - Soluble 1 protein
Crf2-S1 protein
Interleukin-22-Binding Protein protein
Il-22bp protein
Il22bp protein
Zcytor16 protein
IL22RA2 protein
UNQ5793 protein
PRO19598 protein
PRO19822 protein

Information sourced from Uniprot.org

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