Human IL-13 alpha 2 receptor (IL13RA2) protein (Recombinant) (STJP000610)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of human IL-13 receptor alpha2 including an IgG1 human Fc region was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human IL-13 alpha 2 receptor (IL13RA2)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. It is recommended to add 0.1% HSA or BSA for long term storage. |
| Formulation | Lyophilised 0.2 Mu m filtered 50mM Tris, 100mM glycine solution, pH7.5 and 5% trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2ยฐC-8ยฐC C for one month, or at-20ยฐC to-70ยฐC for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ยตg (1EU/ยตg). NA |
| Immunoreactivity | Measured by its ability to bind recombinant human Interleukin-13 at a concentration range of 0.3-8 ng/ml. NA |
Target Information
| Gene Symbol | IL13RA2 |
| Gene ID | 3598 |
| Uniprot ID | I13R2_HUMAN |
| Immunogen | Optimized DNA sequence encoding extracellular domain of human IL-13 receptor alpha2 including an IgG1 human Fc region was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Post Translational Modifications | Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13. |
| Function | Cell surface receptor that plays a role in the regulation of IL-13-mediated responses. Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1. |
| Protein Name | Interleukin-13 Receptor Subunit Alpha-2Il-13 Receptor Subunit Alpha-2Il-13r Subunit Alpha-2Il-13r-Alpha-2Il-13ra2Interleukin-13-Binding ProteinCd Antigen Cd213a2 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-13 Receptor Subunit Alpha-2 proteinIl-13 Receptor Subunit Alpha-2 proteinIl-13r Subunit Alpha-2 proteinIl-13r-Alpha-2 proteinIl-13ra2 proteinInterleukin-13-Binding Protein proteinCd Antigen Cd213a2 proteinIL13RA2 proteinIL13R protein |
Information sourced from Uniprot.org