• Human IL-12B protein (Recombinant) (C-His) (STJP001280)
  • Human IL-12B protein (Recombinant) (C-His) (STJP001280)
  • Human IL-12B protein (Recombinant) (C-His) (STJP001280)
  • Human IL-12B protein (Recombinant) (C-His) (STJP001280)

Human IL-12B protein (Recombinant) (C-His) (STJP001280)

SKU:
STJP001280

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-12B-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human IL12B at 5 Mu g/mL (100 Mu L/well) can bind Human IL12RB1 with a linear range of 0.02-2.7 ng/mL.
Gene Symbol: IL12B
Gene ID: 3593
Uniprot ID: IL12B_HUMAN
Immunogen Region: Ile23-Ser328
Immunogen: Recombinant Human IL-12B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile23-Ser328) of human IL-12B/P40 (Accession #NP_002178.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Known to be C-mannosylated in the recombinant protein.it is not yet known for sure if the wild-type protein is also modified.
Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Protein Name Interleukin-12 Subunit Beta
Il-12b
Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit
Clmf P40
Il-12 Subunit P40
Nk Cell Stimulatory Factor Chain 2
Nksf2
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Cellular Localisation Secreted
Alternative Protein Names Interleukin-12 Subunit Beta protein
Il-12b protein
Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit protein
Clmf P40 protein
Il-12 Subunit P40 protein
Nk Cell Stimulatory Factor Chain 2 protein
Nksf2 protein
IL12B protein
NKSF2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance