| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human IL-12 receptor beta 1-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.2 Mu m filtered PBS solution pH7.4. |
| Dilution Range: | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: | Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: | The activity was determined by its ability to bind Human IL-12B in a linear range of-60 ng/ml in functional ELISA. NA |
| Gene Symbol: | IL12RB1 |
| Gene ID: | 3594 |
| Uniprot ID: | I12R1_HUMAN |
| Immunogen Region: | ECD |
| Immunogen: | DNA sequence encoding extracellular domain of Human IL-12RB1 fused to a C-terminal polyHis tag was expressed in HEK cells. NA |
| Immunogen Sequence: | MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSP |
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-1Il-12 Receptor Subunit Beta-1Il-12r Subunit Beta-1Il-12r-Beta-1Il-12rb1Il-12 Receptor Beta ComponentCd Antigen Cd212 |
| Database Links | Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-12 Receptor Subunit Beta-1 proteinIl-12 Receptor Subunit Beta-1 proteinIl-12r Subunit Beta-1 proteinIl-12r-Beta-1 proteinIl-12rb1 proteinIl-12 Receptor Beta Component proteinCd Antigen Cd212 proteinIL12RB1 proteinIL12R proteinIL12RB protein |
Information sourced from Uniprot.org