Human IGFBP2 protein (Recombinant-Active) (C-His) (STJP011898)

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STJP011898-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human IGFBP2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: IGFBP2
Gene ID: 3485
Uniprot ID: IBP2_HUMAN
Immunogen Region: Glu40-Gln328
Immunogen: Homo sapiens (Human)
Function Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury.
Protein Name Insulin-Like Growth Factor-Binding Protein 2
Ibp-2
Igf-Binding Protein 2
Igfbp-2
Database Links Reactome: R-HSA-381426
Cellular Localisation Secreted
Alternative Protein Names Insulin-Like Growth Factor-Binding Protein 2 protein
Ibp-2 protein
Igf-Binding Protein 2 protein
Igfbp-2 protein
IGFBP2 protein
BP2 protein
IBP2 protein

Information sourced from Uniprot.org

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