| Host: | Mouse/Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This IGFBP-5 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality : | Monoclonal/Monoclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Protein A. Detection Purification: Protein A. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | IGFBP5 |
| Gene ID: | 3488 |
| Uniprot ID: | IBP5_HUMAN |
| Immunogen: | Capture immunogen: Recombinant Human IGFBP-5 protein. Detection Immunogen: Recombinant Human IGFBP-5 protein. |
| Post Translational Modifications | Cleaved by C1S in extracellular space. |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells. Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling. Plays also a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 5 Ibp-5 Igf-Binding Protein 5 Igfbp-5 |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted Cytoplasm Nucleus |
| Alternative Antibody Pair Names | Insulin-Like Growth Factor-Binding Protein 5 antibody pair Ibp-5 antibody pair Igf-Binding Protein 5 antibody pair Igfbp-5 antibody pair IGFBP5 antibody pair IBP5 antibody pair |
Information sourced from Uniprot.org