Human IGFBP-1 (Insulin-Like Growth Factor-Binding Protein 1) Antibody Pair (STJAP00130)

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STJAP00130-50
£499.50
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Host: Mouse/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This IGFBP-1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: IGFBP1
Gene ID: 3484
Uniprot ID: IBP1_HUMAN
Immunogen: Capture immunogen: Recombinant Human IGFBP-1 protein.
Detection Immunogen: Recombinant Human IGFBP-1 protein.
Function Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Plays also a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation.
Protein Name Insulin-Like Growth Factor-Binding Protein 1
Ibp-1
Igf-Binding Protein 1
Igfbp-1
Placental Protein 12
Pp12
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Reactome: R-HSA-9615017
Cellular Localisation Secreted
Alternative Antibody Pair Names Insulin-Like Growth Factor-Binding Protein 1 antibody pair
Ibp-1 antibody pair
Igf-Binding Protein 1 antibody pair
Igfbp-1 antibody pair
Placental Protein 12 antibody pair
Pp12 antibody pair
IGFBP1 antibody pair
IBP1 antibody pair

Information sourced from Uniprot.org

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