Human IFNL2 (Interferon Lambda-2) Sandwich ELISA Kit (STJE0000082)
SPECIFICATIONS
ConjugationBiotin
General Information
| Short Description | This Interferon Lambda-2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma and cell culture supernates. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 7.8 pg/mL |
| Detection Limit | 156-1000 pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Storage Instruction | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time | 4 hours |
| Detection | Colorimetric |
Target Information
| Gene Symbol | IFNL2 |
| Gene ID | 282616 |
| Uniprot ID | IFNL2_HUMAN |
| Sample Type | serum, plasma and cell culture supernates |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-2Ifn-Lambda-2Cytokine Zcyto20Interleukin-28aIl-28a |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Interferon Lambda-2 ELISA kitIfn-Lambda-2 ELISA kitCytokine Zcyto20 ELISA kitInterleukin-28a ELISA kitIl-28a ELISA kitIFNL2 ELISA kitIL28A ELISA kitZCYTO20 ELISA kit |
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Information sourced from Uniprot.org