Human ID2 protein (Recombinant) (N-His-KSI) (STJP015868)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ID2-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ID2 |
| Gene ID | 3398 |
| Uniprot ID | ID2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys2-Gly134 |
Additional Info
| Post Translational Modifications | Ubiquitinated in a ASB4-depedent manner, leading to proteasomal degradation. Phosphorylated in vitro by CDK1, PKA and PKC. |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. |
| Protein Name | Dna-Binding Protein Inhibitor Id-2Class B Basic Helix-Loop-Helix Protein 26Bhlhb26Inhibitor Of Dna Binding 2Inhibitor Of Differentiation 2 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Dna-Binding Protein Inhibitor Id-2 proteinClass B Basic Helix-Loop-Helix Protein 26 proteinBhlhb26 proteinInhibitor Of Dna Binding 2 proteinInhibitor Of Differentiation 2 proteinID2 proteinBHLHB26 protein |
Information sourced from Uniprot.org