Human ID2 protein (Recombinant) (His-Tag) (STJP018098)

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STJP018098
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ID2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ID2
Gene ID: 3398
Uniprot ID: ID2_HUMAN
Immunogen Region: 1-134aa
Accession Number: NP_002157
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF PSELMSNDSK ALCG
Tissue Specificity Highly expressed in early fetal tissues, including those of the central nervous system.
Post Translational Modifications Ubiquitinated in a ASB4-depedent manner, leading to proteasomal degradation. Phosphorylated in vitro by CDK1, PKA and PKC.
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Protein Name Dna-Binding Protein Inhibitor Id-2
Class B Basic Helix-Loop-Helix Protein 26
Bhlhb26
Inhibitor Of Dna Binding 2
Inhibitor Of Differentiation 2
Database Links Reactome: R-HSA-9031628
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Dna-Binding Protein Inhibitor Id-2 protein
Class B Basic Helix-Loop-Helix Protein 26 protein
Bhlhb26 protein
Inhibitor Of Dna Binding 2 protein
Inhibitor Of Differentiation 2 protein
ID2 protein
BHLHB26 protein

Information sourced from Uniprot.org

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