Human ICOS (Inducible T-Cell Co Stimulator) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016016)
SPECIFICATIONS
General Information
| Short Description | This ICOS Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, urine, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 6.2pg/mL |
| Detection Limit | 15.6-1000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | ICOS |
| Gene ID | 29851 |
| Uniprot ID | ICOS_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, urine, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. |
| Post Translational Modifications | N-glycosylated. |
| Function | Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
| Protein Name | Inducible T-Cell CostimulatorActivation-Inducible Lymphocyte Immunomediatory MoleculeCd Antigen Cd278 |
| Database Links | Reactome: R-HSA-1257604 Q9Y6W8-1Reactome: R-HSA-2219530 Q9Y6W8-1Reactome: R-HSA-6811558 Q9Y6W8-1Reactome: R-HSA-9725371Reactome: R-HSA-9927354 Q9Y6W8-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative ELISA Names | Inducible T-Cell Costimulator ELISA kitActivation-Inducible Lymphocyte Immunomediatory Molecule ELISA kitCd Antigen Cd278 ELISA kitICOS ELISA kitAILIM ELISA kit |
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Information sourced from Uniprot.org