| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human IAPP-N-His-SUMO protein was developed from e.coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | IAPP |
| Gene ID: | 3375 |
| Uniprot ID: | IAPP_HUMAN |
| Immunogen Region: | Thr23-Leu89 |
| Immunogen: | Homo sapiens (Human) |
| Function | Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs. |
| Protein Name | Islet Amyloid PolypeptideIappAmylinDiabetes-Associated PeptideDapInsulinoma Amyloid Peptide |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Islet Amyloid Polypeptide proteinIapp proteinAmylin proteinDiabetes-Associated Peptide proteinDap proteinInsulinoma Amyloid Peptide proteinIAPP protein |
Information sourced from Uniprot.org