| Function | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA. |
| Protein Name | Homer Protein Homolog 2Homer-2Cupidin |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmCell MembranePostsynaptic DensitySynapseCell ProjectionStereociliumPostsynaptic Density Of Neuronal CellsThe Stabilization And Clustering Of The Metabotropic Glutamate Receptors Appears To Be Mediated By Isoform 1 And Isoform 2 At The Cell Surface |
| Alternative Protein Names | Homer Protein Homolog 2 proteinHomer-2 proteinCupidin proteinHOMER2 protein |
Information sourced from Uniprot.org
