Human HMGN1 protein (Recombinant) (His-Tag) (STJP016656)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HMGN1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMGN1 |
| Gene ID | 3150 |
| Uniprot ID | HMGN1_HUMAN |
| Accession Number | NP_004956.5 |
| Immunogen | Human |
| Immunogen Region | 1-100aa |
| Immunogen Sequence | MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD LE |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation. Phosphorylation favors cytoplasmic localization. |
| Function | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. |
| Protein Name | Non-Histone Chromosomal Protein Hmg-14High Mobility Group Nucleosome-Binding Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoplasmic Enrichment Upon PhosphorylationThe Rna Edited Version Localizes To The Nucleus |
| Alternative Protein Names | Non-Histone Chromosomal Protein Hmg-14 proteinHigh Mobility Group Nucleosome-Binding Domain-Containing Protein 1 proteinHMGN1 proteinHMG14 protein |
Information sourced from Uniprot.org