Human Hepatocyte growth factor/HGF protein (Recombinant) (C-His) (STJP002813)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Hepatocyte growth factor/HGF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Ser728) of human Hepatocyte growth factor/HGF (Accession #NP_000592.3) fused with and a 6×His t
General Information
| Short Description | Recombinant-Human Hepatocyte growth factor/HGF-C-His protein was developed in hek293 cells using the region Gln32-Ser728. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its ability to induce IL-11 secretion by Saos-2 human osteosarcoma cells. Hjertner, O. et al. (1999) Blood 94:3883. The ED50 for this effect is 2.23-8.91 ng/mL, corresponding to a specific activity of 1.12×105-4.48×1 |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | HGF |
| Gene ID | 3082 |
| Uniprot ID | HGF_HUMAN |
| Immunogen | Recombinant Human Hepatocyte growth factor/HGF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Ser728) of human Hepatocyte growth factor/HGF (Accession #NP_000592.3) fused with and a 6×His t |
| Immunogen Region | Gln32-Ser728 |
| Immunogen Sequence | QRKRRNTIHEFKKSAKTTLI KIDPALKIKTKKVNTADQCA NRCTRNKGLPFTCKAFVFDK ARKQCLWFPFNSMSSGVKKE FGHEFDLYENKDYIRNCIIG KGRSYKGTVSITKSGIKCQP WSSMIPHEHSFLPSSYRGKD LQENYCRNPRGEEGGPWCFT SNPEVRYEVCDIPQCSEVEC MTCNGESYRGLMDHTESGKI CQRWDHQTPHRHKFLPERYP DKGFDDNYCRNPDGQPRPW |
Additional Info
| Function | Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation. |
| Protein Name | Hepatocyte Growth FactorHepatopoietin-AScatter FactorSf Cleaved Into - Hepatocyte Growth Factor Alpha Chain - Hepatocyte Growth Factor Beta Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1257604Reactome: R-HSA-1266695Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785807Reactome: R-HSA-6806942Reactome: R-HSA-6807004Reactome: R-HSA-6811558Reactome: R-HSA-8851805Reactome: R-HSA-8851907Reactome: R-HSA-8865999Reactome: R-HSA-8874081Reactome: R-HSA-8875513Reactome: R-HSA-8875555Reactome: R-HSA-8875656Reactome: R-HSA-8875791Reactome: R-HSA-9734091 |
| Cellular Localisation | |
| Alternative Protein Names | Hepatocyte Growth Factor proteinHepatopoietin-A proteinScatter Factor proteinSf Cleaved Into - Hepatocyte Growth Factor Alpha Chain - Hepatocyte Growth Factor Beta Chain proteinHGF proteinHPTA protein |
Information sourced from Uniprot.org